Daisuke Okuzaki

Hypomorphic Lig4 gene mutation in mice predisposes to Th1-skewing intestinal inflammation

This study shows that hypomorphic Lig4 mutation in mice causes Th1-skewed intestinal inflammation under adaptive immunodeficiency.

Immunological characterization of peritoneal exudate cells in liver cirrhosis patients

This study characterizes peritoneal exudate cells in liver cirrhosis patients using single-cell and bulk RNA sequencing, revealing shifts in immune cell populations and gene expression with disease severity.

Spatial transcriptomics elucidates medulla niche supporting germinal center response in myasthenia gravis thymoma

This study uses spatial transcriptomics to identify medullary niche features in thymoma and thymic hyperplasia associated with myasthenia gravis pathogenesis.

Classification of patients with COVID-19 by blood RNA endotype: A prospective cohort study

The paper identifies an RNA endotype in COVID-19 patients using PRL/TLR3 ratios, showing higher mortality in the high ratio group compared to the low ratio group.

SiCR: Web application for single-cell repertoire analysis and immune profiling

SiCR is a web application for single-cell immune profiling that provides clustering, cell typing, and analysis tools for antigen receptor data.

A novel TGF-β-responsive enhancer regulates SRC expression and epithelial-mesenchymal transition-associated cell migration

This study identifies a TGF-β-responsive enhancer that upregulates SRC expression, driving EMT and cell migration in breast cancer.

Paradoxical tumor suppressive role of the musculoaponeurotic fibrosarcoma gene in colorectal cancer

The paper investigates the tumor-suppressive role of c-MAF in colorectal cancer by analyzing its expression and effects in mouse models and human samples.

Modest static pressure suppresses columnar epithelial cell proliferation in association with cell shape and cytoskeletal modifications

The paper shows that low static pressure suppresses columnar epithelial cell growth, linked to shape changes and cytoskeletal modifications, without affecting the Hippo signaling pathway.