Gordon MG Shepherd

The paper identifies specialized axo-spinous contacts between layer 5 cortical terminals and thalamic spines, showing their functional role in synaptic transmission and motor learning.

This study examines how motor cortex activity in mice changes during unimanual and bimanual food handling tasks, revealing distinct roles for different motor areas.

The paper investigates synaptic circuits in the M2-to-M1 corticocortical pathway in mice, identifying cell-type-specific connections and inhibitory mechanisms.

The paper studies spiking dynamics in mouse S1 and M1 cortices evoked by hand photostimulation, showing propagation speed, layer-specific activity, and PV interneuron involvement.

This study examines cortical activity during food-handling in mice, finding manipulation-specific activity across motor and somatosensory areas with distinct temporal profiles and predictive relationships to forelimb movements.

The paper develops a multiscale model of mouse primary motor cortex to predict cell type-specific, behavior-dependent neural dynamics.

The paper maps excitatory connectivity in the mouse sensorimotor loop for hand/forelimb control, revealing specific cell-type connections across subcortical and cortical regions.

The paper develops a multiscale biophysically detailed model of mouse primary motor cortex to study information flow and dynamics across cell types and frequencies.

NetPyNE is a tool for creating multiscale neuronal network models in NEURON using declarative specifications, enabling efficient simulation and analysis of brain circuits.

The paper identifies a long-range inhibitory circuit in the retrosplenial cortex mediated by CA1 neurons targeting apical tuft dendrites, which interacts with thalamocortical excitation to regulate RSC activity.

The paper studies corticocortical signaling in anesthetized mice using optogenetics and electrophysiology, finding rapid and scalable downstream activity driven by upstream activity.