Siqi Wang

This study identifies splicing degeneration as a hallmark of aging, showing it increases with age and is reversible with calorie restriction or rapamycin.

The paper develops a deep learning method to map SNV effects on translation efficiency, finding that variants influence disease risk through translation regulation.

This study analyzes transcriptomes across 35 human tissues to show sex-dimorphic aging patterns and their links to Alzheimer's disease and hormone levels.

The paper systematically screens RNA binding proteins that enhance circular RNA translation and identifies 68 activators, using a machine learning algorithm to predict additional candidates.