GeneticsPLoS ONEPeer-reviewed
Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice
Chunxing Yang, Tao Qiao, Jia Hui Yu…·Zuoshang Xu
This study shows that low-level overexpression of wild-type TDP-43 in mice causes late-onset, progressive neurodegeneration and paralysis, mimicking aspects of ALS and other TDP-43-related disorders.
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