Author

Issa Olakunle Yusuf

University of Massachusetts Chan Medical SchoolORCID 0000-0003-4480-5946Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 3 Genetics· 1

Signature Assays, Organisms & Methods

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Organism:mouse· 4 Research Focus:differential expression· 2 Approach:experimental assay· 2 Research Focus:gene regulatory network inference· 2 Approach:statistical model· 2 Research Focus:benchmarking· 1 Research Focus:cell type annotation· 1 Research Focus:cell-cell communication· 1

Frequent Co-Authors

Zuoshang XuiD· 3 shared Albino BacollaiD· 1 shared Bu‐Miin HuangiD· 1 shared C.S. Chang· 1 shared Chia‐Ching WuiD· 1 shared Chuan‐Mu CheniD· 1 shared Chunxing Yang· 1 shared Gavin Wayne BritziD· 1 shared

Activity by Year

2021-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 14 mutual co-author links

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3 shared papersNeuroscience

Zuoshang XuORCID

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4 papers

Recent·Most cited

NeurosciencebioRxivPreprintJun 3, 2026

PAD2 knockout reduces myelin protein aggregates, modulates neuroinflammation and protects motor neurons, axons and neuromuscular junction in a SOD1-ALS mouse model

Issa Olakunle Yusuf, Rogerio L.A. Silva, George G Amoako…·Zuoshang Xu

This study shows that PAD2 knockout reduces protein citrullination, improves motor neuron and axon integrity, and modulates neuroinflammation in a SOD1-ALS mouse model.

DOI 10.64898/2026.05.30.729013

mousestatistical model

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NeuroscienceNucleic Acids ResearchPeer-reviewedSep 23, 2025

RNA/DNA Binding Protein TDP43 Regulates DNA Mismatch Repair Genes with Implications for Genome Stability

Vincent E. Provasek, Albino Bacolla, Suganya Rangaswamy…·Muralidhar L. Hegde

This study shows TDP43 regulates DNA mismatch repair genes, affecting genome stability in neurodegenerative and cancer contexts.

13 citationstop 4%

humanmouse

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GeneticsPLoS ONEPeer-reviewedFeb 3, 2022

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

Chunxing Yang, Tao Qiao, Jia Hui Yu…·Zuoshang Xu

This study shows that low-level overexpression of wild-type TDP-43 in mice causes late-onset, progressive neurodegeneration and paralysis, mimicking aspects of ALS and other TDP-43-related disorders.

57 citationstop 2%

mouseexperimental assay

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NeuroscienceMolecular NeurobiologyPeer-reviewedJan 9, 2021

Fibroblast growth factor 9 stimulates neurite outgrowth through NF-kB signaling in striatal cell Huntington's disease models

Issa Olakunle Yusuf, Hsiu-Mei Chen, Pei‐Hsun Cheng…·Shang‐Hsun Yang

This study shows that FGF9 promotes neurite outgrowth in HD models by activating NF-kB signaling, which upregulates structural and synaptic proteins.

20 citations

mouseproteomics

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