Huaibin Cai

Sex-Dependent Effects of Glutamatergic Disruption on Dopaminergic Neuron Subtype Vulnerable in Parkinson's Disease

This study shows that disrupting NMDA receptor-mediated glutamatergic input to ALDH1A1+ dopaminergic neurons causes sex-specific feeding abnormalities linked to Parkinson's disease.

Subtype-Specific Roles of Nigrostriatal Dopaminergic Neurons in Motor and Associative Learning

This study investigates the functional roles of two nigrostriatal dopaminergic neuron subtypes in motor and associative learning using genetic and chemogenetic approaches in mice.

Patchy Striatonigral Neurons Modulate Locomotor Vigor in Response to Environmental Valence

This study identifies a subtype of striatonigral neurons that modulate locomotor speed based on environmental valence in mice.

Patch and matrix striatonigral neurons differentially regulate locomotion

This study identifies a subtype of striatonigral neurons that regulate locomotion speed based on environmental valence through genetic and optogenetic manipulations in mice.

Striosomes constrain locomotor vigor with respect to an innate valence differential

The paper investigates how striosomes influence locomotor speed based on contextual valence using ablation, calcium imaging, and chemogenetics in a modified Light/Dark box test.

Low-level overexpression of wild type TDP-43 causes late-onset, progressive neurodegeneration and paralysis in mice

This study shows that low-level overexpression of wild-type TDP-43 in mice causes late-onset, progressive neurodegeneration and paralysis, mimicking aspects of ALS and other TDP-43-related disorders.

Deficiency in endocannabinoid synthase DAGLB contributes to Parkinson's disease and dopaminergic neuron dysfunction

This study shows that deficiency in DAGLB, an endocannabinoid synthase, contributes to Parkinson's disease by impairing dopaminergic neuron function and motor learning, with potential therapeutic implications for 2-AG augmentation.