Long-term antiplatelet therapy protects against cerebral but not parenchymal amyloid plaque formation and neurodegeneration in transgenic mice of Alzheimers disease
Lili Donner, Laura Mara Toska, Marlene Pils, Fabian Rehn, Oliver Bannach, Margitta Elvers
This study shows that long-term antiplatelet therapy with clopidogrel reduces cerebral amyloid angiopathy and soluble Aβ42 levels but not parenchymal amyloid plaques or neurodegeneration in APP23 mice.
bioRxiv · Jun 30, 2025 · PreprintPathology