Jens Rolff

Towards forecasting antimicrobial resistance evolution: concordance of in vitro and in vivo studies

This study compares in vitro and in vivo antimicrobial resistance evolution data to show that experimental data can predict in vivo resistance emergence.

Cross-linked agarose-gelatine beads as a substrate for investigating biofilms of bacterial pathogens

This paper introduces a hydrogel substrate for studying bacterial biofilms, showing improved biofilm growth and virulence factor production compared to glass beads.

The danger hypothesis of virulence evolution

The paper develops a mathematical model based on danger theory to show that cost-based immune activation favors avirulence in microbes, proposing the danger hypothesis of virulence evolution.

Tachykinin-related peptide signalling is important for the immune response of the mealworm beetle Tenebrio molitor L.

This study investigates the role of tachykinin-related peptide (TRP) signaling in the immune response of Tenebrio molitor, showing that TRP and TRPR genes are downregulated during immune activation and that TRPs modulate antimicrobial peptide expression and phenoloxidase activity.

Immune-mediated indirect interaction between gut microbiota and bacterial pathogens

This study investigates whether Imd-dependent AMPs mediate indirect interactions between gut microbiota and pathogens in a tripartite context, finding that Imd-independent AMPs and microbiota-mediated immune priming influence infection outcomes.

Fermentation of Agricultural By-products and Zinc Supplementation: A Synergistic Approach to Mealworm Microbiome Optimization

This study investigates the effects of fermented spinach and zinc supplementation on mealworm microbiome composition and health, finding increased probiotic bacteria and reduced pathogen presence.

Speed Matters: Accelerated Pharmacokinetics Reduce Persisters in Escherichia coli

The paper shows that faster drug concentration changes reduce persister cells in E. coli, suggesting that pharmacokinetics affects persister formation.

Boosting Bug Farms: A Meta-Analysis on Probiotic Effects in Insect Rearing

This paper conducts a meta-analysis of probiotic effects on insect rearing, finding increased growth rates but no significant impact on microbiome diversity.

Bottlenecks and Resistance Evolution against an Antimicrobial 1 Peptide

The paper investigates how population bottlenecks affect bacterial resistance evolution to antimicrobial peptides in E. coli, finding that mutator strains in large populations develop higher resistance.

Antibiotic-induced Recombination in Escherichia coli Requires the Formation of DNA Double-Strand Breaks

This study shows that fluoroquinolones increase recombination in E. coli by causing DNA double-strand breaks, unlike other antibiotics that do not affect recombination.

Genomic signature of experimental adaptation of Staphylococcus aureus to a natural combination of insect antimicrobial peptides

This study evolves Staphylococcus aureus to resist insect antimicrobial peptides and finds mutations in ytr and nsa operons confer resistance, with varying fitness costs.

Cationic Peptides Facilitate Iron-induced Mutagenesis in Bacteria

The paper shows that cationic peptides like LL-37 enhance iron-induced mutagenesis in Pseudomonas aeruginosa by enabling iron entry, leading to DNA damage via Fenton reactions.