Yuxuan Miao

Integrated analysis of stemness-associated immune modulatory circuits in squamous cell carcinomas

The paper identifies SOX2 as a master regulator of immune modulatory circuits in tumor-initiating stem cells, enabling immunosuppressive myeloid cell development.

Comparative single cell analysis of wound and cancer identifies the metabolic dialogues between tumor initiating stem cells and macrophages

This study compares single-cell RNA sequencing data from wound healing and cancer to identify metabolic differences between tumor-associated macrophages and wound-associated macrophages, highlighting SOX2High stem cells as key regulators.

Tumor-Initiating Cells Fine-tune the Plasticity of Neutrophils to Sculpt a Protective Niche

This study identifies tumor-initiating cells that modulate neutrophil plasticity to create a protective niche, preventing immunotherapy effectiveness.

SFyNCS detects oncogenic fusions involving non-coding sequences in cancer

SFyNCS detects oncogenic fusions involving non-coding sequences in cancer using transcriptomic data and validates them with genomic structural variations.