Cancer BiologybioRxivPreprint
LSH-mediated resolution of R-loops mitigates transcription-replication conflicts to preserve genomic stability in prostate cancer cells
Kai Ni, Yu Zhang, Kun Chan Zheng…·Qiang Fu
This study shows LSH resolves R-loops in prostate cancer cells, reducing transcription-replication conflicts and DNA damage, and identifies LSH as a potential therapeutic target.
DOI 10.1101/2025.06.04.657812