Hannah L. Waterman

This study shows that morning insulin exposure enhances afternoon hepatic glucose disposal in dogs by increasing glucose-mediated mechanisms, though maximal effects also require elevated afternoon insulin.

This study investigates whether morning hyperglucagonemia affects the priming effects of morning hyperinsulinemia on subsequent hepatic glucose metabolism in dogs.

The paper investigates how morning insulin delivery route affects afternoon hepatic glucose uptake, finding that direct hepatic insulin signaling, not indirect actions, drives the second meal phenomenon.

The study shows that prolonged morning hyperinsulinemia improves hepatic glucose uptake and glycogen storage during an afternoon clamp compared to shorter, higher-rate insulin delivery.