Dale S. Edgerton

Morning Elevation in Insulin Enhances Afternoon Hepatic Glucose Disposal in Dogs by Increasing Both Insulin Signaling and Glucose Action

This study shows that morning insulin exposure enhances afternoon hepatic glucose disposal in dogs by increasing glucose-mediated mechanisms, though maximal effects also require elevated afternoon insulin.

Morning Glucagon Disrupts Insulin Induced Hepatic Metabolic Memory and Subsequent Afternoon Glucose Metabolism in Canines

This study investigates whether morning hyperglucagonemia affects the priming effects of morning hyperinsulinemia on subsequent hepatic glucose metabolism in dogs.

Morning Engagement of Hepatic Insulin Receptors Improves Afternoon Hepatic Glucose Disposal and Storage

The paper investigates how morning insulin delivery route affects afternoon hepatic glucose uptake, finding that direct hepatic insulin signaling, not indirect actions, drives the second meal phenomenon.

Duration of Morning Hyperinsulinemia Determines Hepatic Glucose Uptake and Glycogen Storage Later in the Day

The study shows that prolonged morning hyperinsulinemia improves hepatic glucose uptake and glycogen storage during an afternoon clamp compared to shorter, higher-rate insulin delivery.