Author

Sergio Castro‐Gomez

University of BonnORCID 0000-0002-1581-474XUnclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Neuroscience· 2 Genetic & Genomic Medicine· 1

Signature Assays, Organisms & Methods

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Research Focus:differential expression· 2 Organism:mouse· 2 Approach:statistical model· 2 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Assay:scRNA-seq· 1

Frequent Co-Authors

Ana Maria Menezes Vieira-Saecker· 2 shared Eicke LatziD· 2 shared Michael Thomas HenekaiD· 2 shared Tao LiiD· 2 shared Valentin SteiniD· 2 shared Alexandra Marzena Morawiec· 1 shared Alexandra Tibelius· 1 shared Alexej KnausiD· 1 shared

Activity by Year

2023-2025 · peak 2/yr

Co-Author Collaboration Network

10 top collaborators · 20 mutual co-author links

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2 shared papersNeuroscience

Ana Maria Menezes Vieira-Saecker

Mutual co-authors in cluster

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3 papers

Recent·Most cited

NLRP3 inhibition maintains microglia architecture and enhances behavioral recovery after traumatic brain injury

Sergio Castro‐Gomez, Ana Maria Menezes Vieira-Saecker, Juan Ignacio Muñoz-Manco, Tao Li, Ida Kulińska, Felix D. Weiss, Felix Meissner, Stephanie Schwartz, Valentin Stein, Eicke Latz, Michael Thomas Heneka

This study investigates the role of NLRP3 inhibition in reducing neuroinflammation and improving behavioral recovery after traumatic brain injury.

bioRxiv · Jun 25, 2025 · PreprintNeuroscience

ASC contributes to sustained glial reactivity and mild cognitive impairment after closed-head injury

Tao Li, Sergio Castro‐Gomez, Pablo Botella Lucena, Ana Maria Menezes Vieira-Saecker, Sarah Schwartz, Yushuang Deng, Yingying Ding, Valentin Stein, Eicke Latz, Michael Thomas Heneka

This study shows that ASC sustains neuroinflammation and contributes to cognitive deficits after mild closed-head injury.

bioRxiv · Jun 19, 2025 · PreprintNeuroscience

Next-generation phenotyping integrated in a national framework for patients with ultra-rare disorders improves genetic diagnostics and yields new molecular findings

Axel Schmidt, Magdalena Danyel, Kathrin Grundmann, Theresa Brunet, Hannah Klinkhammer, Tzung‐Chien Hsieh, Hartmut Engels, Sophia Peters, Alexej Knaus, Shahida Moosa, Luisa Averdunk, Felix Boschann, Henrike L. Sczakiel, Sarina Schwartzmann, Martin A. Mensah, , Lilian Tamara Kaufmann

The paper evaluates a structured diagnostic framework for ultra-rare diseases, showing improved genetic diagnoses and novel gene-disease associations using exome sequencing and AI tools.

medRxiv · Apr 19, 2023 · PreprintGenetic & Genomic Medicine