Michael Thomas Heneka

This study shows that postprandial hypertriglyceridemia activates microglia to promote satiety via an ASC-dependent signaling pathway, which is sexually dimorphic and disrupted in obesity.

The paper identifies oligodendrocyte subtype changes in Parkinson's disease across species, linking them to disease progression and clinical outcomes.

This study develops a high-throughput platform using human cerebral organoids to screen for compounds that reverse HSV-1-induced neuroinflammation biomarkers associated with Alzheimer's disease.

This study investigates the role of NLRP3 inhibition in reducing neuroinflammation and improving behavioral recovery after traumatic brain injury.

This study shows that ASC sustains neuroinflammation and contributes to cognitive deficits after mild closed-head injury.

This paper introduces ELSI-Net, a deep learning method for automated Locus Coeruleus segmentation and feature extraction in aging and Alzheimer's Disease dementia, showing high agreement with manual ratings and correlations to CSF biomarkers.

The paper identifies Rps24c/S24-PKE as a novel marker for neuroinflammation and neurodegeneration through cell type-specific alternative splicing in mouse brains.

The paper links cognitive reserve to brain activity during memory formation, showing it moderates the impact of Alzheimer's pathology on cognitive performance and predicts slower decline.

This study shows that silencing ApoE in the brain with divalent siRNAs reduces amyloid plaques in Alzheimer's mice without affecting systemic cholesterol.

The paper uses Gaussian process multikernel modeling to predict memory performance and CSF biomarkers in ageing and Alzheimer's disease using MRI and other data.

This study shows that SFRP1 from astrocytes promotes microglial activation in acute and chronic neuroinflammation, suggesting it as a therapeutic target.

This study identifies Arg1+ microglia as a distinct subtype in female mice, showing their role in cognitive function through dendritic spine maturation and behavior.

The paper assesses memorability of photographs in healthy controls, subjective cognitive decline, and mild cognitive impairment, identifying images with diagnostic potential.