Giulio G. Muccioli

Alzheimer's disease-associated Presenilin 2 N141I mutation impairs neuronal lipid homeostasis and mitochondrial dynamics through selective downregulation of the Golgi exchange factor Gbf1

This study shows that the N141I PS2 mutation disrupts lipid homeostasis and mitochondrial dynamics by downregulating Gbf1, suggesting a new amyloid-independent pathway in Alzheimer's disease.

Identification of an endocannabinoid gut-brain vagal mechanism controlling food reward and energy homeostasis

This study identifies a gut-brain vagal mechanism involving endocannabinoids that regulates food reward and energy homeostasis, showing that peripheral CB1 receptor inhibition reduces palatable eating.