Serena Stanga

This study shows that the N141I PS2 mutation disrupts lipid homeostasis and mitochondrial dynamics by downregulating Gbf1, suggesting a new amyloid-independent pathway in Alzheimer's disease.

The paper shows that BBB damage in aging leads to brain iron deposits through astrocyte-neuron interactions and the Hepc/Fpn1 pathway.

The paper shows that PS1 and PS2 deficiency in primary neurons and astrocytes does not cause mitochondrial dysfunction, contrasting with findings in immortalized cell lines.

This study identifies NPAS4 as a target of APP regulation, showing APP controls excitatory/inhibitory synaptic inputs by modulating NPAS4 expression in neurons.