Julien Castel

This study identifies PTH1R signaling in AgRP neurons as a mechanism controlling feeding behavior and nutrient partitioning through distinct kinase activation and lipophagic processes.

This study identifies the claustrum's role in appetitive feeding by showing its neurons and circuitry reduce high-fat diet intake.

This study shows that triglycerides modulate D2R-neuron activity in the nucleus accumbens during appetitive behaviors, with effects dependent on metabolic state and diet.

This study shows that peripheral CB1R inhibition reduces food intake and improves metabolism in obese mice through both vagal-dependent brainstem activation and vagal-independent hypothalamic effects.

This study investigates how the gut-brain vagal axis influences mesolimbic dopamine dynamics and reward behaviors, challenging the traditional brain-centric view of reward processing.

This study investigates the role of the gut-brain vagal axis in hippocampal memory processes and finds it essential for long-term recognition memories and synaptic plasticity.

This paper investigates the role of NAPE-PLD in the ventral tegmental area, showing its impact on reward behaviors, feeding, and energy homeostasis through transcriptomic analysis and genetic manipulations.

This study identifies ANKK1's role in striatal DR2-expressing neurons, linking it to reward, metabolism, and behaviors associated with the A1 allele of TaqIA.

This study identifies a gut-brain vagal mechanism involving endocannabinoids that regulates food reward and energy homeostasis, showing that peripheral CB1 receptor inhibition reduces palatable eating.

This study shows that acute changes in blood glucose levels affect the entry and action of GLP-1R agonists in the brain, influencing energy homeostasis and weight loss.