Axelle E. Loriot

The paper identifies gut microbiota-derived metabolites that protect against muscle atrophy in cancer cachexia by restoring amino acid homeostasis through the serine biosynthesis pathway.

This study identifies mitochondrial dysfunction as a key feature of brain senescence in telomerase-deficient mice, linking telomere attrition to impaired mitochondrial function and region-specific neuronal vulnerability.

This study identifies HNF1B and NPHP3 mutations as causes of a new pancreatic disease, ciliogenic pancreatopathy, characterized by acinar atrophy and adipose replacement, and links ciliary dysfunction to pancreatic dysfunction in humans and mice.

This study shows that adipocyte beta3-adrenergic receptor activation protects against high-fat diet-induced cardiac damage by promoting beige fat formation and adipose-cardiac communication.

This study shows that mixed acid fermentation products from Lachnospira eligens counteract myotube atrophy and links reduced gut anaerobiosis in AML patients to decreased muscle strength.

This study shows that the N141I PS2 mutation disrupts lipid homeostasis and mitochondrial dynamics by downregulating Gbf1, suggesting a new amyloid-independent pathway in Alzheimer's disease.

The paper develops CTexploreR to analyze cancer-germline genes, showing X-linked genes are DNA methylation dependent and exhibit maternal imprinting in early embryos.

The paper reveals how ALT+ cells sustain cGAS-STING activation through spatial regulation and lysosomal degradation of STING and ECTR species, suggesting therapeutic targets for ALT+ tumors.

This study uses spatial transcriptomics to analyze two gallbladder cancer patients, showing distinct progression paths and the role of SEMA4A repression in tumor development.