ImmunologyCell chemical biologyPeer-reviewed
A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation
Aude Sylvain, Natacha Stoehr, Fupeng Ma…·Zuni I. Bassi
This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.