Author

Ashley A. Burke

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

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Immunology· 1

Signature Assays, Organisms & Methods

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Approach:deep learning· 1 Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1 Organism:mouse· 1 Organism:non-human primate· 1 Assay:proteomics· 1

Frequent Co-Authors

Alexander N.R. WeberiD· 1 shared Alfred G. ZimmerliniD· 1 shared Andreas HofmanniD· 1 shared Artiom CernijenkoiD· 1 shared Aude Sylvain· 1 shared Azeddine ElhajoujiiD· 1 shared Callum J. DicksoniD· 1 shared Charles A. WartchowiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperImmunology

Alexander N.R. WeberORCID

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1 paper

Recent·Most cited

A cereblon (CRBN) molecular glue degrader of NIMA-related kinase 7 (NEK7) reveals a context-dependent role in NLRP3 inflammasome activation

Aude Sylvain, Natacha Stoehr, Fupeng Ma, Artiom Cernijenko, Martin Schröder, Maryam Khoshouei, Melanie Vogelsanger, Michel Schoenboerner, Ashley A. Burke, Pasupuleti Rao, Jonathan M. Solomon, Joshiawa Paulk, Lei Xu, Janet Dawson, Damien Begue, , Zuni I. Bassi

This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.

Cell chemical biology · Jul 1, 2025Peer-reviewedImmunology