Alexander N.R. Weber

This study shows human NLRC4 can directly sense cytosolic flagellin without NAIP, while NAIP may inhibit this response.

This study shows that chitin oligomers of specific lengths activate the NLRP3 inflammasome and induce innate immune training through phagocytosis and methyl transferase activity.

This study shows CHI3L1 interacts with chitosan and heparan sulfate to activate TLR2 signaling, revealing HS as a co-receptor for CHI3L1 and its role in inflammation.

This study reports a novel mode of NLRP3 activation in zebrafish through cryo-EM structure analysis, revealing a distinct oligomeric arrangement and activation mechanism compared to humans.

This study determines the crystal structure of E. coli Nissle 1917 flagellin and shows that hypervariable regions affect motility but not TLR5 recognition.

This study shows that NLRP3 directly senses intracellular potassium ions, with K+ levels regulating its conformation and inflammasome activation.

This paper characterizes BAL-0028, a novel NLRP3 inhibitor with a distinct binding site and mechanism, showing potent inhibition of human and primate NLRP3 and efficacy in a peritonitis model.

This paper identifies NK7-902, a CRBN molecular glue degrader of NEK7, showing partial inhibition of NLRP3 inflammasome activation in humans and full activity in mice, but only transient effects in non-human primates.

This paper shows that BTK and MMP-9 negatively regulate NLRP3 inflammasome activity in neutrophils, affecting cytokine and NET release.

The paper identifies two distinct NLRP3 activation pathways, one dependent on decameric cage formation and another independent of the MTOC and TGN.

This study identifies chitin oligomers as the smallest immunologically active motif and TLR2 as the primary receptor for chitin, showing size-dependent signaling and therapeutic potential.