Guoli Ji

stAPAminer: Mining Spatial Patterns of Alternative Polyadenylation for Spatially Resolved Transcriptomic Studies

The paper introduces stAPAminer, a toolkit for analyzing spatial patterns of alternative polyadenylation in spatial transcriptomics data, revealing reproducible spatial APA dynamics in mouse olfactory bulb.

Learning association for single-cell transcriptomics by integrating profiling of gene expression and alternative polyadenylation

The paper introduces scLAPA, a toolkit that improves cell-cell association and clustering in scRNA-seq by integrating gene expression and alternative polyadenylation data.

Overdispersed gene expression characterizes schizophrenic brains

The paper identifies genes and gene sets with increased expression variability in schizophrenia, linking this variability to genetic factors and brain development processes.

Aging shapes the population-mean and -dispersion of gene expression in human brains

This study identifies age-related changes in gene expression across brain regions, showing both mean and dispersion effects, and highlights genotype-dependent responses.

Exploiting aberrant mRNA expression in autism for gene discovery and diagnosis

This paper introduces a new gene expression analysis method to identify genetic heterogeneity in ASD by detecting aberrant expression variability, leading to the discovery of diagnostic biomarkers.