Author

James J Cai

Texas A&M University

Listed by name: these papers carry no ORCID for this author, so different people with the same name may be mixed together.

Biology Disciplines

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Genetics· 3 Neuroscience· 1

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 4 Research Focus:differential expression· 4 Approach:statistical model· 4 Organism:human· 3 Research Focus:cell type annotation· 1 Approach:experimental assay· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Ence Yang· 2 shared Gang Wang· 2 shared Guoli JiiD· 2 shared Jinting GuaniD· 2 shared Jizhou Yang· 2 shared Ashok Kumar ShettyiD· 1 shared Avery LeMaire· 1 shared Beiyan Zhou· 1 shared

Activity by Year

2016-2025 · peak 3/yr

Co-Author Collaboration Network

10 top collaborators · 18 mutual co-author links

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2 shared papersGenetics

Ence Yang

Mutual co-authors in cluster

Author profile →

4 papers

Recent·Most cited

Intranasal Human NSC-Derived EVs Therapy Can Restrain Inflammatory Microglial Transcriptome, and NLRP3 and cGAS-STING Signaling, in Aged Hippocampus

Leelavathi Narayana Madhu, Maheedhar Kodali, Shama Rao, Sahithi Attaluri, Raghavendra Upadhya, Goutham Shankar, Bing Shuai, Yogish Somayaji, Shruthi V. Ganesh, Vignesh S. Kumar, Jeswin E. James, Padmashri A Shetty, Avery LeMaire, Xiaolan Rao, James J Cai, Ashok Kumar Shetty

This study shows that intranasal hiPSC-NSC-EVs reduce neuroinflammaging in aged mice by modulating microglial transcriptome and signaling pathways.

bioRxiv · Mar 2, 2025 · PreprintNeuroscience

Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action

Ence Yang, Gang Wang, Jizhou Yang, Beiyan Zhou, Yanan Tian, James J Cai

This study identifies two mechanisms, epistasis and destabilizing mutations, that contribute to gene expression variability in humans through variance-association mapping analyses.

bioRxiv · Aug 18, 2016Genetics

Aging shapes the population-mean and -dispersion of gene expression in human brains

Candice L Brinkmeyer-Langford, Jinting Guan, Guoli Ji, James J Cai

This study identifies age-related changes in gene expression across brain regions, showing both mean and dispersion effects, and highlights genotype-dependent responses.

bioRxiv · May 19, 2016Genetics

Exploiting aberrant mRNA expression in autism for gene discovery and diagnosis

Jinting Guan, Ence Yang, Jizhou Yang, Gang Wang, Yong Zeng, Guoli Ji, James J Cai

This paper introduces a new gene expression analysis method to identify genetic heterogeneity in ASD by detecting aberrant expression variability, leading to the discovery of diagnostic biomarkers.

Human Genetics · Apr 30, 2016Peer-reviewedGenetics