Gang Wang

Fibroblast-encoded inflammatory memory orchestrates recurrent skin inflammation via NNMT-dependent metabolic remodeling

This paper identifies NNMT as a metabolic-epigenetic regulator in fibroblasts that sustains inflammatory memory and drives recurrent skin inflammation by maintaining a pro-inflammatory niche.

Longitudinal single-cell profiling links RUNX1T1 to lineage transition and maintenance in treatment-induced neuroendocrine prostate cancer

This study uses longitudinal single-cell RNA sequencing to identify RUNX1T1 as a key regulator in the transition and maintenance of treatment-induced neuroendocrine prostate cancer.

Production and functional verification of 8-gene (GGTA1, CMAH, β4GalNT2, hCD46, hCD55, hCD59, hTBM, hCD39)-edited donor pigs for xenotransplantation

The paper edits 8 genes in pigs to reduce immune rejection and tests their effectiveness in xenotransplantation to non-human primates.

Highly efficient healing of critical sized articular cartilage defect in situ using a chemically nucleoside-modified mRNA-enhanced cell therapy

This paper demonstrates that chemically modified mRNA enhances bone marrow stem cell therapy to efficiently repair critical-sized cartilage defects in rats within 6 weeks.

CRISPR-Cas12b-assisted nucleic acid detection platform

The paper develops HOLMESv2, a one-step nucleic acid detection platform combining LAMP and Cas12b for convenient and efficient detection.

Epistasis and destabilizing mutations shape gene expression variability in humans via distinct modes of action

This study identifies two mechanisms, epistasis and destabilizing mutations, that contribute to gene expression variability in humans through variance-association mapping analyses.

Exploiting aberrant mRNA expression in autism for gene discovery and diagnosis

This paper introduces a new gene expression analysis method to identify genetic heterogeneity in ASD by detecting aberrant expression variability, leading to the discovery of diagnostic biomarkers.