Dynamic and decay kinetics of H3 variants in live cells reveal the pivotal role of HIRA/NSD2 in maintaining the distinct H3.3 specific chromatin landscape
Vishal Nehru, David A. Ball, Abhishek Mukherjee, Daisuke Kurotaki, Ajay B. Chitnis, Tatiana S. Karpova, Keiko Ozato
This study uses live-cell imaging to analyze H3.3 and H3.1 dynamics, revealing that HIRA and NSD2 regulate their turnover and mobility, with H3.3 showing faster decay and dependence on transcriptional activity.
bioRxiv · May 21, 2024 · PreprintCell Biology