Tatiana Karpova

QuantiTrack, a MATLAB GUI, unifies single-molecule detection, tracking, quality control and mobility analyses; for glucocorticoid receptor, hormone washout cut bound fraction, dwell times and low-mobility occupancy.

This study shows heparan sulfate regulates GPC3 nanoscale organization and Wnt receptor assembly in hepatoma cells, enhancing β-catenin signaling.

The paper identifies DNA replication machinery components as critical for TAD boundary re-establishment during DNA replication.

The paper tracks chromatin dynamics across seven orders of magnitude in human and mouse cells, finding strongly subdiffusive behavior with limited sensitivity to transcription and histone modifications.

This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

This study uses live-cell imaging to analyze H3.3 and H3.1 dynamics, revealing that HIRA and NSD2 regulate their turnover and mobility, with H3.3 showing faster decay and dependence on transcriptional activity.

The paper uses Bayesian methods to analyze kinetic transcription parameters in yeast under stress, revealing fast bursting dynamics within slower cycles.