David A. Ball

QuantiTrack: A unified software to study protein dynamics in living cells

QuantiTrack, a MATLAB GUI, unifies single-molecule detection, tracking, quality control and mobility analyses; for glucocorticoid receptor, hormone washout cut bound fraction, dwell times and low-mobility occupancy.

Heparan Sulfate Controls Nanoscale Assembly of GPC3-Wnt Receptor Complexes

This study shows heparan sulfate regulates GPC3 nanoscale organization and Wnt receptor assembly in hepatoma cells, enhancing β-catenin signaling.

Kinetic proofreading as a mechanism for transcriptional specificity in living human cells

This study shows that transcriptional specificity is achieved through kinetic proofreading, where promoters discriminate specific TF interactions based on dwell time rather than occupancy.

Transcription factors form a ternary complex with NIPBL/MAU2 to localize cohesin at enhancers

The paper identifies LxxLL motifs in NIPBL that regulate its interaction with MAU2 and steroid receptors, forming a ternary complex with GR to facilitate enhancer localization of cohesin.

Mesoscale landscaping of the TRIM protein family reveals a novel human condensatopathy

This study investigates mesoscale organization of TRIM proteins, finding that TRIM8 truncations cause condensatopathy by disrupting condensation and signaling pathways.

Dynamic and decay kinetics of H3 variants in live cells reveal the pivotal role of HIRA/NSD2 in maintaining the distinct H3.3 specific chromatin landscape

This study uses live-cell imaging to analyze H3.3 and H3.1 dynamics, revealing that HIRA and NSD2 regulate their turnover and mobility, with H3.3 showing faster decay and dependence on transcriptional activity.

Bayesian analysis dissects kinetic modulation during non-stationary gene expression

The paper uses Bayesian methods to analyze kinetic transcription parameters in yeast under stress, revealing fast bursting dynamics within slower cycles.

Single-molecule imaging reveals the interplay between transcription factors, nucleosomes, and transcriptional bursting

This study uses single-molecule imaging to show that Gal4 dwell time determines transcriptional burst size in yeast, with nucleosomes reducing dwell time and affecting transcriptional bursting kinetics.