Brian Luke

The paper constructs genome-wide conditional degron libraries in yeast to improve functional genomics by enabling controlled protein degradation and avoiding suppressor mutations.

The paper investigates the repair of rNMP-derived nick lesions during DNA replication and identifies a genetic network essential for this process.

The paper shows that TERRA RNA-DNA hybrids regulate senescence in yeast survivors by modulating telomere shortening and HDR.

This study identifies chromatin modifiers and recombination factors essential for telomere folding in yeast, which is lost during replicative senescence.

The paper investigates the differential regulation of RNase H1 and H2 in yeast, showing RNase H2 is cell cycle-dependent while RNase H1 acts independently of cell cycle stage.