Anton Khmelinskii

The paper investigates how the SCFDas1 ubiquitin ligase recognizes C-terminal degrons, identifying a conserved binding site and key residues involved in substrate recognition.

This study identifies Gid11 as a substrate receptor for the GID ubiquitin ligase in budding yeast, revealing its role in regulating metabolic transitions by targeting glycolytic factors during ethanol metabolism.

The paper constructs genome-wide conditional degron libraries in yeast to improve functional genomics by enabling controlled protein degradation and avoiding suppressor mutations.

The paper identifies over 5000 C-degrons in budding yeast and shows that the SCF ubiquitin ligase targets ~40% of them via the F-box receptor Das1.

The paper investigates the repair of rNMP-derived nick lesions during DNA replication and identifies a genetic network essential for this process.

This study identifies a family of FYVE-type-RING finger proteins as E3 ligases that cooperate with Ubc13-Mms2 in K63-polyubiquitylation at internal membranes across species.

The paper describes a C-SWAT library for high-throughput tagging of yeast ORFs and validates it by tagging the yeast proteome with fluorescent proteins.

This study evaluates how green fluorescent protein (greenFP) maturation kinetics and proteasomal degradation affect tandem fluorescent protein timers (tFTs), identifying greenFPs that degrade efficiently and guidelines for tFT design.