Author

Yi Zhou

Regeneron (United States)ORCID 0000-0002-1650-4591Unclaimed ORCID profile · follow to get notified of new preprints

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Yi Zhou4 papers · Fudan University

Biology Disciplines

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Biochemistry· 1

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Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell signaling & trafficking· 1 Assay:cryo-EM· 1 Approach:experimental assay· 1 Organism:human· 1 Approach:microscopy & imaging analysis· 1 Research Focus:protein structure prediction· 1

Frequent Co-Authors

Annan SI CookiD· 1 shared Jennifer L. JonesiD· 1 shared Jing CaoiD· 1 shared Luke L. McGoldrickiD· 1 shared Mark W. SleemaniD· 1 shared Matthew C. FrankliniD· 1 shared Panayiotis E. Stevis· 1 shared Raymond Leidich· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperBiochemistry

Annan SI CookORCID

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1 paper

Recent·Most cited

Structural basis for constitutive activation of oncogenic gp130 mutants in human inflammatory hepatocellular adenomas

Yi Zhou, Jing Cao, Trudy F. Ramlall, Luke L. McGoldrick, Jennifer L. Jones, Annan SI Cook, Raymond Leidich, Mark W. Sleeman, William C. Olson, Panayiotis E. Stevis, Matthew C. Franklin

This study identifies structural mechanisms of gp130 mutant activation in IHCAs using cryo-EM and mutagenesis, revealing two distinct dimer conformations and their activation dependencies.

bioRxiv · Nov 11, 2025 · PreprintBiochemistry