FMR1 gene therapy restores activity-driven inhibition and prevents audiogenic seizures in Fmr1-/y mice
Beatriz Maio, Aditi Singh, Ralph Hector…·Emily K. Osterweil
This study shows that AAV-FMR1 gene therapy restores auditory circuit function and prevents audiogenic seizures in Fmr1-/y mice by normalizing translation and excitatory/inhibitory balance in the inferior colliculus.