Jim Selfridge

This study shows that AAV-FMR1 gene therapy restores auditory circuit function and prevents audiogenic seizures in Fmr1-/y mice by normalizing translation and excitatory/inhibitory balance in the inferior colliculus.

This study shows SALL4 binds across the genome to shape chromatin and gene expression in stem cells.

The paper identifies cross-species biomarkers and mechanisms in Rett Syndrome using gene therapy and multi-omic analysis in mice.

This study shows that MeCP2's binding to non-CG methylation, specifically mCAC trinucleotides, is critical for normal brain function, as demonstrated by severe Rett syndrome-like phenotypes in mice with a modified MeCP2 domain.

The paper identifies SALL4 as a protein that interprets DNA base composition by binding to AT-rich motifs, and shows its role in controlling cell fate through regulation of AT-rich gene expression.

The paper investigates the molecular effects of non-canonical MeCP2 mutations in neurons and mice, finding they impact known domains rather than causing new molecular mechanisms of Rett syndrome.

The paper shows MeCP2 binds to mCG and mCAC sequences in mouse brain, with binding density correlating with transcriptional regulation of neuronal genes.