Mycobacterium tuberculosis complex lineage 5 exhibits high levels of within-lineage genomic diversity and differing gene content compared to the type strain H37Rv
N'Dira Sanoussi, Mireia Coscollá, Boatema Ofori-Anyinam, Isaac Darko Otchere, Martín Antonio, Stefan Niemann, Julian Parkhill, Simon R. Harris, Dorothy Yeboah‐Manu, Sébastien Gagneux, Leen Rigouts, Dissou Affolabi, Bouke Catherine de Jong, Conor Joseph Meehan
The paper identifies high within-lineage genomic diversity and gene content differences in Mycobacterium tuberculosis complex lineage 5 compared to H37Rv, affecting transmission analysis and suggesting the need for alternative reference genomes.
Microbial Genomics · Jul 9, 2021Peer-reviewedGenetics