Frank Delvigne

The paper shows that reduced cellular responsiveness in Pseudomonas putida predicts population collapse and demonstrates a feedback control system to maintain stable bioprocesses.

This paper develops a dual-control system for plasmid copy number in E. coli using temperature shifts and RNAI-based circuits, showing synergistic effects in real-time PCN regulation.

The paper introduces synthetic niches using genetic toggle switches to control microbial co-cultures but finds they are vulnerable to mutational escape under cultivation.

This study evaluates the Segregostat system's ability to control stress responses in microbial cells under industrial bioreactor conditions using automated flow cytometry.

The paper identifies a Fitness-Entropy Compensation mechanism that stabilizes cell populations by balancing growth and gene expression through increased expression diversity.

This paper introduces AAMN, an automated method to control microbial co-cultures by adjusting metabolic niches, showing its effectiveness in stabilizing both cooperative and competitive cultures.

The paper investigates how reducing the switching cost of burdensome gene circuits in E. coli improves population homogeneity and productivity.

The paper identifies conditions for intrinsic phenotypic oscillations in bacterial cultures without genetic oscillators or external forcing, validated in Bacillus subtilis.

The paper demonstrates that substrate pulsing in microbial co-cultures can stabilize interactions by creating periodic fitness advantages, validated through computational modeling and experimental testing.

This paper quantifies single-cell phenotypic diversity in microbial communities using Raman spectroscopy and the Hill diversity framework to study stress-induced changes.