Juan A. Martínez

The paper introduces synthetic niches using genetic toggle switches to control microbial co-cultures but finds they are vulnerable to mutational escape under cultivation.

The paper identifies a Fitness-Entropy Compensation mechanism that stabilizes cell populations by balancing growth and gene expression through increased expression diversity.

This paper introduces AAMN, an automated method to control microbial co-cultures by adjusting metabolic niches, showing its effectiveness in stabilizing both cooperative and competitive cultures.

The paper investigates how reducing the switching cost of burdensome gene circuits in E. coli improves population homogeneity and productivity.

The paper demonstrates that substrate pulsing in microbial co-cultures can stabilize interactions by creating periodic fitness advantages, validated through computational modeling and experimental testing.