Author

Kennedy S. Humphrey

Roswell Park Comprehensive Cancer CenterORCID 0000-0002-1692-2523Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Cancer Biology· 2

Signature Assays, Organisms & Methods

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Assay:bulk RNA-seq· 2 Organism:human· 2 Research Focus:cancer & tumor microenvironment· 1 Research Focus:cell type annotation· 1 Research Focus:differential expression· 1 Approach:experimental assay· 1 Assay:spatial transcriptomics· 1 Approach:statistical model· 1

Frequent Co-Authors

Agnieszka Katarzyna WitkiewicziD· 2 shared Erik S. KnudseniD· 2 shared Ethan V. AbeliD· 2 shared Jianxin WangiD· 2 shared Katherine J. CrawfordiD· 2 shared Mark D. LongiD· 2 shared Bharani Muppavarapu· 1 shared Eduardo Cortes GomeziD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

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10 top collaborators · 41 mutual co-author links

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2 shared papersCancer Biology

Agnieszka Katarzyna WitkiewiczORCID

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2 papers

Recent·Most cited

Cancer BiologyCommunications BiologyPeer-reviewedJul 30, 2026

HNF1A is a novel BRD4 target and critical for BET-inhibitor response in pancreatic ductal adenocarcinoma

Kennedy S. Humphrey, Katherine J. Crawford, Bharani Muppavarapu…·Ethan V. Abel

This paper identifies HNF1A as a BRD4 target and shows that BET-inhibitors' antitumor effects in PDAC depend on HNF1A ablation.

DOI 10.1038/s42003-026-10685-z

humanbulk RNA-seq

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Cancer BiologyMolecular CancerPeer-reviewedJul 29, 2025

Targeting FGFR4 Abrogates HNF1A-driven Metastasis in Pancreatic Ductal Adenocarcinoma

Katherine J. Crawford, Kennedy S. Humphrey, Eduardo Cortes Gomez…·Ethan V. Abel

This study identifies HNF1A as an oncogenic driver of PDAC metastasis through upregulation of FGFR4 and shows that FGFR4 inhibition reduces metastasis in vitro and in vivo.

4 citations

humanbulk RNA-seq

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