Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP
Justin M. Waldern, Colin D. Taylor, Catherine A. Giannetti, Patrick S. Irving, Scott R. Allen, Mingyi Zhu, Rolf Backofen, David H. Mathews, Kevin M. Weeks, Alain Laederach
The paper investigates the structural determinants of inverted Alu-mediated backsplicing in the HIPK3 gene using SHAPE-JuMP and finds that long-range Alu-mediated base pairs are required for circularization, but not full-length Alu elements.
Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology