Author

Justin M. Waldern

University of North Carolina at Chapel HillORCID 0000-0002-9262-5694Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Genomics· 1 Molecular Biology· 1

Signature Assays, Organisms & Methods

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Organism:human· 2 Approach:statistical model· 2 Assay:bulk RNA-seq· 1 Research Focus:differential expression· 1 Assay:DNA methylation· 1 Research Focus:gene regulatory network inference· 1 Research Focus:spatial domain detection· 1 Research Focus:variant effect prediction· 1

Frequent Co-Authors

Alain LaederachiD· 2 shared David H. MathewsiD· 2 shared Kevin M. WeeksiD· 2 shared Abhishek DeyiD· 1 shared Anthony M. MustoeiD· 1 shared Catherine A. GiannettiiD· 1 shared Colin D. TayloriD· 1 shared Jayashree KumariD· 1 shared

Activity by Year

2022-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 33 mutual co-author links

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2 shared papersMolecular Biology

Alain LaederachORCID

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2 papers

Recent·Most cited

Structural determinants of inverted Alu-mediated backsplicing revealed by -MaP and -JuMP

Justin M. Waldern, Colin D. Taylor, Catherine A. Giannetti, Patrick S. Irving, Scott R. Allen, Mingyi Zhu, Rolf Backofen, David H. Mathews, Kevin M. Weeks, Alain Laederach

The paper investigates the structural determinants of inverted Alu-mediated backsplicing in the HIPK3 gene using SHAPE-JuMP and finds that long-range Alu-mediated base pairs are required for circularization, but not full-length Alu elements.

Nucleic Acids Research · May 10, 2025Peer-reviewedMolecular Biology

Quantitative prediction of variant effects on alternative splicing using endogenous pre-messenger RNA structure probing

Jayashree Kumar, Lela Lackey, Justin M. Waldern, Abhishek Dey, Anthony M. Mustoe, Kevin M. Weeks, David H. Mathews, Alain Laederach

The paper predicts variant effects on alternative splicing using structural probing data and a computational framework, achieving 90% accuracy for splice-altering variants.

eLife · Jun 13, 2022Peer-reviewedGenomics