Patrick S. Irving

The paper investigates the structural determinants of inverted Alu-mediated backsplicing in the HIPK3 gene using SHAPE-JuMP and finds that long-range Alu-mediated base pairs are required for circularization, but not full-length Alu elements.

This paper introduces fpocketR to detect RNA ligand-binding pockets and validates them with Frag-MaP, identifying new sites capable of binding drug-like ligands.

RNAvigate provides a Python library for efficiently exploring RNA chemical probing datasets through automated parsing and visualization of diverse structural and functional data.

The paper identifies distinct structural domains in the MUNC lncRNA that regulate different promyogenic genes through cis and trans mechanisms.