Author

Flávio A. Amaral

ORCID 0000-0002-1695-0612Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Microbiology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 1 Research Focus:host-pathogen & immune response· 1 Organism:mouse· 1 Assay:proteomics· 1

Frequent Co-Authors

Alesandra Côrte Reis· 1 shared Brenda Gonçalves ResendeiD· 1 shared Caio T. FagundesiD· 1 shared Carolina B R Mascarenhas· 1 shared Cristiano Xavier LimaiD· 1 shared Daiane BoffiD· 1 shared Daniele G SouzaiD· 1 shared João Paulo Pezzini Barbosa· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 45 mutual co-author links

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1 shared paperMicrobiology

Alesandra Côrte Reis

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1 paper

Recent·Most cited

Activation of bradykinin receptor B1 promotes desensitization of CXCR2 in neutrophils during severe sepsis and contributes to disease progression in mice.

Raquel Duque do Nascimento Arifa, Carolina B R Mascarenhas, Lívia C R Rossi, Maria Eduarda Freitas Silva, Larissa Mendes Barbosa Lucas, João Paulo Pezzini Barbosa, Daiane Boff, Brenda Gonçalves Resende, Livia Duarte Tavares, Alesandra Côrte Reis, Vanessa Pinho, Flávio A. Amaral, Caio T. Fagundes, Cristiano Xavier Lima, Mauro Martins Teixeira, Daniele G Souza

This study shows that BDKRB1 activation worsens sepsis by impairing neutrophil migration and CXCR2 function, and inhibiting BDKRB1 improves survival and bacterial clearance in mice.

JCI Insight · Dec 7, 2025Peer-reviewedMicrobiology