John B. Moldovan

The paper identifies a 46 nucleotide domain in Alu RNA essential for retrotransposition by enabling SRP9/14 binding and ribosomal association.

The paper shows HeLa strains differ in Alu retrotransposition efficiency, with distinct mechanisms for SINE RNA mobilization involving ORF2p.

DeepMosaic detects mosaic single nucleotide variants without control samples using deep convolutional neural networks, achieving high accuracy and uncovering many variants missed by existing methods.

This study identifies somatic SNVs in non-cancerous human brain tissues and establishes best practices for detecting low-frequency variants.

The paper introduces a machine learning method to detect somatic L1 insertions in human brain tissue, revealing their widespread distribution in neurons and glia and potential role in neuropsychiatric diseases.