Developmental BiologybioRxivPreprint
Optogenetic BMP4 models symmetry breaking and primitive streak formation in hPSCs
Alena Streletskaia, Caleb J. Bashor, Aryeh Warmflash
This paper introduces LightBMP, an optogenetic tool to control BMP4 in hPSCs, showing spatial BMP4 patterns can drive symmetry breaking and primitive streak formation without mechanical cues.