Caleb J. Bashor

This paper introduces LightBMP, an optogenetic tool to control BMP4 in hPSCs, showing spatial BMP4 patterns can drive symmetry breaking and primitive streak formation without mechanical cues.

The paper introduces CLASSIC, a platform that maps sequence-to-function relationships in synthetic biology by combining long- and short-read sequencing to analyze gene circuits.

This paper engineers synthetic phosphorylation signaling networks in human cells to enable dynamic sensing and suppression of activated T cells.

This study shows that cooperative self-assembly of transcriptional regulators can improve regulatory specificity and long-term stability of synthetic gene circuits in yeast.

The paper develops a framework linking protein-protein interaction strength to information transmission and dynamical response in signaling networks, finding a speed-information trade-off.

The paper introduces eVOLVER, a scalable DIY framework for automated cell growth and laboratory evolution, demonstrating its versatility through yeast experiments and novel millifluidic modules.