Author

Samantha R. Guinn

Johns Hopkins UniversityORCID 0000-0002-4558-8915Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Research Focus:cell signaling & trafficking· 2 Research Focus:cell type annotation· 2 Approach:experimental assay· 2 Assay:bulk RNA-seq· 1 Research Focus:cancer & tumor microenvironment· 1 Research Focus:development & morphogenesis· 1 Research Focus:host-pathogen & immune response· 1 Organism:human· 1

Frequent Co-Authors

Alexander KominiD· 1 shared Alexei HernandeziD· 1 shared Benjamin Barrett· 1 shared Brayan PereziD· 1 shared Brendan Foley· 1 shared Christopher R. ShubertiD· 1 shared Courtney D. CannoniD· 1 shared Daniel J. ZabranskyiD· 1 shared

Activity by Year

2024-2025 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 24 mutual co-author links

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1 shared paperImmunology

Alexander KominORCID

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2 papers

Recent·Most cited

Cancer associated fibroblasts drive epithelial to mesenchymal transition and classical to basal change in pancreatic ductal adenocarcinoma cells with loss of IL-8 expression

Samantha R. Guinn, Brayan Perez, Joseph A. Tandurella, Mili Ramani, Jae Woo Lee, Daniel J. Zabransky, Emma Kartalia, Jignasha G. Patel, Haley Zlomke, Norman G. Nicolson, Sarah M. Shin, Benjamin Barrett, Nicholas Sun, Alexei Hernandez, Erin M. Coyne, , Jacquelyn W. Zimmerman

The paper investigates how cancer-associated fibroblasts (CAF) influence tumor cell behavior in pancreatic ductal adenocarcinoma by driving EMT and altering cell subtypes, with IL-8 playing a key modulatory role.

bioRxiv · Jan 7, 2025 · PreprintCancer Biology

T cell responsiveness to IL-10 defines the immunomodulatory effect of costimulation blockade via anti-CD154 and impacts transplant survival

Marcos Iglesias, Darrel Bibicheff, Alexander Komin, Maria Chicco, Samantha R. Guinn, Brendan Foley, Giorgio Raimondi

This study shows that T cell responsiveness to IL-10 determines the effectiveness of costimulation blockade therapy in transplant models, impacting graft survival.

bioRxiv · Jun 12, 2024 · PreprintImmunology