Saikat Chakrabarti

The paper presents a computational model of yeast Top1 and identifies key residues mediating its interaction with Rpc82, a subunit of RNA polymerase III.

This study shows PDK4 links ERUPR and mitoUPR, affecting mitochondrial integrity in aging and neurodegeneration.

This study identifies the androgen receptor as a key regulator in cervical cancer cell migration through network biology and experimental validation.

This study analyzes the mutation and evolutionary dynamics of SARS-CoV-2 variants of concern in India from 2020 to 2023, identifying key mutations and their structural impacts.

The paper investigates the role of cytoplasmic capping enzyme (cCE) in maintaining cap homeostasis of target mRNAs during stress and recovery.

The paper investigates the localization and function of axonemal microtubule inner proteins and dynein docking complex members in vertebrate motile cilia, revealing structural and functional differences between (9+2) and (9+0) cilia.

The paper analyzes SARS-CoV2 genomic diversity and phylodynamic patterns in India, identifying prevalent clades and mutation dynamics across 2020.

The paper identifies primary miRNAs that coordinate the biogenesis of secondary miRNAs to regulate immune response in activated macrophages.

The paper identifies that Rheb-mTOR activation restores miR-146 activity in glial cells, reducing amyloid beta-induced cytokine production and rescuing cognitive impairment in a rat Alzheimer's model.

The paper develops the Co-Var method to identify co-evolutionary pairings in protein-protein interaction complexes and validates its performance against existing methods.

APODHIN integrates multi-omics data into a human interactome network to identify key molecular players and their interconnections in cancer, providing tools for analysis and visualization.

PresRAT identifies bacterial small-RNA sequences and their targets, predicting 60,518 sRNAs and 2447 targets across 54 and 13 bacterial genomes, respectively.

The paper introduces Leish-ExP, a database of Leishmania exclusive proteins, identified through whole genome comparative analysis across five species.

The paper investigates NBC-2, a naproxen bio-conjugate with amino alcohol, showing enhanced anti-inflammatory effects by inhibiting NF-κB signaling and reducing pro-inflammatory proteins in macrophages.