Author

Mohamed-Raafet Ammar

St. Jude Children's Research HospitalORCID 0000-0002-1753-9366Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

Click to filter author papers

Signature Assays, Organisms & Methods

Click to filter · or open tag

Approach:experimental assay· 1 Research Focus:protein folding & dynamics· 1

Frequent Co-Authors

Brian G. O’FlynniD· 1 shared Kelly A. ChurioniD· 1 shared Martin TurkiD· 1 shared Matthew J. CuneoiD· 1 shared Nafiseh Sabri· 1 shared Ömer GüllülüiD· 1 shared Tanja MittagiD· 1 shared Xinrui GuiiD· 1 shared

Activity by Year

2025-2025 · peak 1/yr

Co-Author Collaboration Network

8 top collaborators · 28 mutual co-author links

Click any collaborator node to inspect or filter shared papers

Focal author (center)Selected co-authorORCID co-authorUnlinked name

Curved chords = mutual co-authorship

1 shared paperBiophysics

Brian G. O’FlynnORCID

Mutual co-authors in cluster

Author profile →

1 paper

Recent·Most cited

The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants

Matthew J. Cuneo, Ömer Güllülü, Mohamed-Raafet Ammar, Xinrui Gui, Kelly A. Churion, Martin Turk, Brian G. O’Flynn, Nafiseh Sabri, Tanja Mittag

The paper shows that SPOP activity is regulated by the equilibrium between circular double donut structures and linear filaments, with mutations shifting this balance and affecting substrate turnover and localization.

bioRxiv · Jun 19, 2025 · PreprintBiophysics