Author

Matthew J. Cuneo

St. Jude Children's Research HospitalORCID 0000-0002-1475-6656Unclaimed ORCID profile · follow to get notified of new preprints

Biology Disciplines

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Biophysics· 1 Cell Biology· 1

Signature Assays, Organisms & Methods

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Approach:experimental assay· 2 Assay:ChIP-seq· 1 Research Focus:chromatin & epigenetic regulation· 1 Research Focus:drug response / drug discovery· 1 Research Focus:gene regulatory network inference· 1 Organism:human· 1 Research Focus:protein folding & dynamics· 1 Assay:proteomics· 1

Frequent Co-Authors

Tanja MittagiD· 2 shared Aaron B. TayloriD· 1 shared Adithi DandaiD· 1 shared Anang A. ShelatiD· 1 shared Aseem Z. AnsariiD· 1 shared Ashraf MohammediD· 1 shared Beisi XuiD· 1 shared Brandon Michael YoungiD· 1 shared

Activity by Year

2025-2026 · peak 1/yr

Co-Author Collaboration Network

10 top collaborators · 37 mutual co-author links

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2 shared papersCell Biology

Tanja MittagORCID

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2 papers

Recent·Most cited

BRD4 recruitment desilences transcription without erasure or depletion of repressive chromatin

Christopher J. Brandon, Sarah Robinson-Thiewes, Mangesh H. Kaulage, Wojciech Rosikiewicz, Matthew J. Cuneo, Joseph Brett, Jindpreet Kandola, Walter H. Lang, Jonathan A. Low, Ashraf Mohammed, Adithi Danda, Sam Rider, M Valentine, Jason Ochoada, Brandon Michael Young, , Aseem Z. Ansari

This study shows that BRD4 recruitment can desilence transcription within repressive chromatin without removing H3K9me3 or HP1, challenging conventional models of chromatin regulation.

bioRxiv · Apr 13, 2026 · PreprintCell Biology

The equilibrium between two quaternary assembly states determines the activity of SPOP and its cancer mutants

Matthew J. Cuneo, Ömer Güllülü, Mohamed-Raafet Ammar, Xinrui Gui, Kelly A. Churion, Martin Turk, Brian G. O’Flynn, Nafiseh Sabri, Tanja Mittag

The paper shows that SPOP activity is regulated by the equilibrium between circular double donut structures and linear filaments, with mutations shifting this balance and affecting substrate turnover and localization.

bioRxiv · Jun 19, 2025 · PreprintBiophysics