Tanja Mittag

This study shows multi-component biomolecular condensates suppress amyloid formation by sequestering proteins, limiting their availability for fibril formation.

This study shows that BRD4 recruitment can desilence transcription within repressive chromatin without removing H3K9me3 or HP1, challenging conventional models of chromatin regulation.

This study compares two models of transcription factor function in yeast, showing that Gcn4 can act through both soluble complexes and condensates, with DNA binding suppressing phase separation.

The paper shows that SPOP activity is regulated by the equilibrium between circular double donut structures and linear filaments, with mutations shifting this balance and affecting substrate turnover and localization.

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

The paper develops a machine learning model to predict phase separation propensities of disordered proteins from sequence, identifying 5% of human IDRs likely to undergo homotypic phase separation.

The paper introduces optical techniques to measure molecular interaction strength and physical properties of protein condensates, showing how sequence variations and environmental factors affect these properties.

The paper shows that biomolecular condensates generate interphase electric potentials due to ion asymmetry, suggesting they function as mesoscale capacitors.