Xinrui Gui

This study shows multi-component biomolecular condensates suppress amyloid formation by sequestering proteins, limiting their availability for fibril formation.

The paper shows that SPOP activity is regulated by the equilibrium between circular double donut structures and linear filaments, with mutations shifting this balance and affecting substrate turnover and localization.

The paper shows that separable interactions in A1-LCD allow tunable metastability of condensates, which can suppress amyloid fibril formation even with ALS mutations.

This study shows PARylation regulates RNP granule dynamics and neurotoxicity of disease-related RNA-binding proteins, with PARP inhibition reducing neurotoxicity in ALS models.