Minxian Qian

This study shows that loss of Ythdf3 in mice causes Danon disease-like features due to impaired Sox9 mRNA decay, and targeted therapy with AAV-shRNA against Sox9 improves disease outcomes.

This study identifies a novel body temperature/Hsp70-Sirt7-Cry1 axis that maintains circadian phase coherence in mouse liver by regulating Sirt7 activity.

This study identifies SIRT6 as a non-enzymatic coactivator of GATA4 that protects against doxorubicin-induced cardiotoxicity by enhancing GATA4 acetylation through recruitment of Tip60.

The paper shows that boosting ATM activity with chloroquine extends lifespan in nematodes and mice by improving DNA repair and metabolic health.